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Pathogenesis of septicaemia.

C S Easmon1

  • 1Department of Medical Microbiology, Wright-Fleming Institute, St Mary's Hospital Medical School, London, UK.

The Journal of Antimicrobial Chemotherapy
|April 1, 1990
PubMed
Summary

This review explores how bacteria evade host defenses during septicaemia (blood poisoning). It also examines septic shock, focusing on lipopolysaccharide and tumor necrosis factor roles and potential therapies.

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Area of Science:

  • Microbiology
  • Immunology
  • Pathogenesis

Background:

  • Septicaemia pathogenesis involves bacterial evasion of host defenses.
  • Septic shock is a severe complication of septicaemia.

Purpose of the Study:

  • To review bacterial resistance mechanisms against host defenses.
  • To examine the role of lipopolysaccharide and tumor necrosis factor in septic shock.
  • To discuss potential therapeutic implications.

Main Methods:

  • Literature review of bacterial pathogenesis.
  • Analysis of host-pathogen interactions.
  • Review of molecular mechanisms in septic shock.

Main Results:

  • Bacteria employ various strategies to resist opsonization, phagocytosis, intracellular killing, and complement lysis.
  • Lipopolysaccharide and tumor necrosis factor are key mediators in the development of septic shock.
  • Understanding these mechanisms offers insights into therapeutic strategies.

Conclusions:

  • Bacterial evasion tactics are crucial in septicaemia development.
  • Lipopolysaccharide and tumor necrosis factor signaling pathways are central to septic shock.
  • Targeting these pathways may improve septicaemia and septic shock treatment.

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