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Related Experiment Video

Updated: May 13, 2026

Dissection, Culture, and Analysis of Xenopus laevis Embryonic Retinal Tissue
10:22

Dissection, Culture, and Analysis of Xenopus laevis Embryonic Retinal Tissue

Published on: December 23, 2012

Normal maturation involves systematic changes in binocular visual connections in Xenopus laevis.

S Grant, M J Keating

    Nature
    |September 9, 2011
    PubMed
    Summary
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    Neuronal connections in Xenopus laevis undergo significant, ordered changes during development. These adaptive neural rewiring events are driven by evolving functional requirements, specifically altered eye alignment.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Visual System Research

    Background:

    • Neuronal connections in vertebrates often refine during development or in response to stimuli.
    • The developing visual system presents opportunities to study adaptive neural changes.

    Purpose of the Study:

    • To investigate ordered changes in neuronal connections during normal development.
    • To examine how functional requirements influence neural circuit development in Xenopus laevis.

    Main Methods:

    • Electrophysiological recordings were used to study the intertectal system in Xenopus laevis.
    • Developmental stages from late larval to post-metamorphic were analyzed.

    Main Results:

    • The intertectal system in Xenopus laevis undergoes major, ordered changes during development.

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    Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System
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    Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System

    Published on: February 11, 2022

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    Last Updated: May 13, 2026

    Dissection, Culture, and Analysis of Xenopus laevis Embryonic Retinal Tissue
    10:22

    Dissection, Culture, and Analysis of Xenopus laevis Embryonic Retinal Tissue

    Published on: December 23, 2012

    A Simple Behavioral Assay for Testing Visual Function in Xenopus laevis
    08:34

    A Simple Behavioral Assay for Testing Visual Function in Xenopus laevis

    Published on: June 12, 2014

    Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System
    09:00

    Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System

    Published on: February 11, 2022

  • These neural changes correlate with developmental shifts in interocular alignment and visual field expansion.
  • Connections within the intertectal system adapt to maintain representation of corresponding visual space despite changing eye positions.

    • Conclusions:

    • Neuronal connections can undergo significant, adaptive changes in response to normal developmental shifts in functional demands.
    • The intertectal system of Xenopus laevis provides a model for studying experience-dependent neural development and rewiring.