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[Inflammatory reaction and laboratory tests: interleukin-1].
T Kasahara1, T Akaboshi, H Tsunoda
1Department of Medical Biology and Parasitology, Jichi Medical School, Tochigi pref.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 1, 1990
Summary
Interleukin 1 (IL 1) exhibits diverse functions, some mediated by induced cytokines like IL 6 and IL 8. Its role in immunity and disease, including rheumatoid arthritis, is explored.
Area of Science:
- Immunology
- Cytokine Biology
Context:
- Interleukin 1 (IL 1) is a key cytokine with pleiotropic effects.
- Understanding IL 1's functions is crucial for comprehending immune responses and inflammatory conditions.
Purpose:
- To summarize recent advancements in IL 1 research.
- To elucidate the multifaceted roles of IL 1 and its induced cytokines.
- To establish assays for IL 1 quantification and assess its levels in disease.
Summary:
- IL 1 possesses varied in vitro and in vivo functions, some indirectly mediated by induced cytokines such as IL 6 and IL 8.
- IL 1's roles in bacterial infection resistance, radioresistance, and anti-tumor activity are investigated for direct vs. indirect mechanisms.
- Bioassays and ELISA assays for IL 1 alpha and IL 1 beta were developed, enabling measurement in biological fluids.
Impact:
- Provides insights into the complex regulatory network of cytokines.
- Highlights the significance of IL 1 in immune regulation, infection, and cancer.
- Establishes methodologies for IL 1 assessment, aiding in the study of inflammatory diseases like rheumatoid arthritis.