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Published on: June 7, 2011
Polymorphisms of matrix metalloproteinases in myocardial infarction: a meta-analysis
1Department of Gerontology, the first affiliated hospital of Nanjing Medical University, Nanjing 210029, PRC, China.
Context:
The literature provides no clear answer as to whether matrix metalloproteinases (MMPs) polymorphisms increases risk of myocardial infarction (MI).
Objective:
Our purpose was to help clarify the inconsistent findings of MMPs polymorphisms and MI susceptibility and identify which MMP polymorphism might play an active role in the occurrence of MI.
Data Sources:
Articles were identified by a Medline search and citation tracking.
Study Selection:
Eligible articles were case-control studies of MMPs polymorphisms and MI which met our prespecified criteria.
Data Extraction:
Data were independently extracted by two authors according to a predefined protocol. Incongruities were settled by consensus decision.
Results And Conclusions:
18 potentially eligible articles were identified. In a combined analysis, the 5A allele of the MMP-3 5A/6A polymorphism was associated with MI (OR 1.21, 95% CI 1.01 to 1.46, p=0.04), suggesting its role in plaque rupture. In the subgroup analysis by ethnicity, significantly increased risk was found among East Asians (OR 1.39, 95% CI 1.01 to 1.91, p=0.04), whereas no significant association was detected in Caucasian populations. In addition, there were significant associations of the MMP-9 -1562C→T polymorphism with MI (OR 1.14, 95% CI 1.02 to 1.27, p=0.02), whereas the heterogeneity of the studies showed no significance (I(2)=13.7%, p=0.32). This meta-analysis demonstrated that the MMP-3 5A/6A and MMP-9 -1562 C→T polymorphisms are risk factors associated with increased MI susceptibility, but these associations vary in different ethnic populations.
Insights
Certain matrix metalloproteinases (MMPs) gene variations, specifically MMP-3 5A/6A and MMP-9 -1562 C→T, are linked to increased myocardial infarction (MI) risk. These associations differ across ethnic groups, notably in East Asians.
Area of Science:
- Genetics and Cardiovascular Disease
- Molecular Biology and Medicine
Background:
- The relationship between matrix metalloproteinases (MMPs) gene polymorphisms and myocardial infarction (MI) risk remains unclear.
- Existing literature presents conflicting findings regarding this association.
Purpose of the Study:
- To clarify the inconsistent findings on MMPs polymorphisms and MI susceptibility.
- To identify specific MMP polymorphisms that may influence the occurrence of MI.
Main Methods:
- Systematic literature search using Medline and citation tracking.
- Inclusion of eligible case-control studies on MMPs polymorphisms and MI.
- Independent data extraction by two authors with consensus for discrepancies.
Main Results:
- The MMP-3 5A/6A polymorphism (5A allele) was associated with increased MI risk (OR 1.21), particularly in East Asians (OR 1.39).
- The MMP-9 -1562C→T polymorphism showed a significant association with MI (OR 1.14) with low study heterogeneity.
- The identified associations varied across different ethnic populations.
Conclusions:
- MMP-3 5A/6A and MMP-9 -1562 C→T polymorphisms are identified as risk factors for myocardial infarction.
- These genetic variations contribute to MI susceptibility, with ethnic-specific risk profiles.
- The findings highlight the role of specific MMP polymorphisms in cardiovascular disease risk.
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