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Updated: May 29, 2026

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells
Published on: September 15, 2021
A generic organ based ontology system, applied to vertebrate heart anatomy, development and physiology
Laura M F Bertens1, Joris Slob, Fons J Verbeek
1Imaging & Bioinformatics, LIACS, Leiden University, The Netherlands.
Abstract:
We present a novel approach to modelling biological information using ontologies. The system interlinks three ontologies, comprising anatomical, developmental and taxonomical information, and includes instances of structures for different species. The framework is constructed for comparative analyses in the field of evolutionary development. We have applied the approach to the vertebrate heart and present four case studies of the functionality of the system, focusing on cross-species comparisons, developmental studies, physiological studies and 3D visualisation.
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