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Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Probiotic therapy: immunomodulating approach toward urinary tract infection
Sarika Amdekar1, Vinod Singh, Desh Deepak Singh
1Department of Microbiology, Barkatullah University, Hoshangabad Road, Habibganj, Bhopal, 462026 Madhya Pradesh, India.
Current Microbiology
|September 9, 2011
Summary
Lactobacillus species combat urinary tract infections (UTIs) by maintaining a healthy genital environment and activating immune responses. This probiotic approach offers a new strategy against recurrent UTIs caused by bacteria like Escherichia coli.
Area of Science:
- Microbiology
- Immunology
- Urology
Background:
- Urinary tract infections (UTIs) are common, often caused by Escherichia coli, with high recurrence rates.
- Loss of Lactobacillus species in the genital microbiota correlates with increased UTI incidence.
- Antimicrobial agents are effective but do not prevent UTIs from recurring.
Purpose of the Study:
- To review the role of Lactobacillus species in combating UTIs.
- To explore the potential of probiotics and Toll-like receptor (TLR) therapy for genitourinary health.
- To understand the immunomodulatory mechanisms of Lactobacillus species.
Main Methods:
- Review of current literature on Lactobacillus species, UTIs, and TLR signaling.
- Analysis of the interaction between Lactobacillus species, E. coli, and host immune pathways.
- Examination of TLR2 and TLR4 activation by probiotics and pathogens.
Main Results:
- Lactobacillus species maintain a low vaginal pH, produce hydrogen peroxide, and inhibit E. coli growth.
- Lactobacillus activates Toll-like receptor-2 (TLR2), leading to IL-10 and MyD88 production.
- E. coli activates TLR4, inducing IL-12, ERK, and JNK, which downregulate inflammation.
Conclusions:
- Lactobacillus species offer a promising probiotic strategy for UTI prevention and treatment.
- TLR-based therapies utilizing probiotics represent a novel approach to genitourinary health.
- Understanding these immune pathways can lead to the development of effective genitourinary vaccines.
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