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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cytotoxic C21 and C22 terpenoid-derived metabolites from the sponge Ircinia sp
Jui-Hsin Su1, Shang-Wei Tseng, Mei-Chin Lu
1Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan, Republic of China. x2219@nmmba.gov.tw
Abstract:
One novel C21 terpenoidal natural product, ircinolin A (2), two new C22 furanoterpene metabolites, 15-acetylirciformonin B (3) and 10-acetylirciformonin B (4), and two known compounds, irciformonin B (1) and irciformonin F (5), were isolated from the sponge Ircinia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data. Moreover, the absolute configuration of 1 was determined by Mosher's method. Among these metabolites, 2 is the first C21 terpenoid-derived metabolite to be reported from this genus. Compounds 1 and 3-5 exhibited significant cytotoxic activity against K562, DLD-1, HepG2, and Hep3B cancer cell lines.
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