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Updated: May 29, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
Published on: August 12, 2019
Direct functionalization of (un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: two
Michael Ghobrial1, Michael Schnürch, Marko D Mihovilovic
1Institute of Applied Synthetic Chemistry, Vienna University of Technology, 1060 Vienna, Austria.
Abstract:
A highly facile, straightforward synthesis of 1-(3-indolyl)-tetrahydroisoquinolines was developed using either simple copper or iron catalysts. N-protected and unprotected tetrahydroisoquinolines (THIQ) could be used as starting materials. Extension of the substrate scope of the pronucleophile from indoles to pyrroles and electron-rich arenes was realized. Additionally, methoxyphenylation is not limited to THIQ but can be carried out on isochroman as well, again employing iron and copper catalysis.
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