Related Experiment Video
Updated: May 29, 2026

13:47
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
Incorporating life expectancy in glaucoma care.
C Wesselink1, R Stoutenbeek, N M Jansonius
1Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Eye (London, England)
|September 10, 2011
Summary
Glaucoma patients can use a new tool to estimate their risk of vision loss based on age and disease severity, helping personalize treatment decisions and improve long-term eye health outcomes.
Area of Science:
- Ophthalmology
- Clinical decision-making
- Public health
Background:
- Glaucoma is a leading cause of irreversible blindness worldwide.
- Predicting long-term visual impairment risk is crucial for personalized glaucoma management.
- Current methods often do not adequately integrate patient age and life expectancy.
Purpose of the Study:
- To determine combinations of age and glaucoma severity where patients are unlikely to experience vision impairment.
- To develop a tool for estimating lifetime visual impairment risk in glaucoma patients.
Main Methods:
- Utilized residual life expectancy data from Statistics Netherlands.
- Derived glaucoma progression rates from published studies.
- Calculated baseline visual field damage (Mean Deviation) predicting a -20 dB endpoint at life expectancy, considering age and progression rates.
Main Results:
- Developed a user-friendly graphical tool for estimating visual impairment probability.
- The tool integrates age, current glaucomatous damage, and individual progression rates.
- Provides accurate risk assessment for personalized glaucoma care.
Conclusions:
- This novel tool allows clinicians to integrate life expectancy into glaucoma care decisions.
- Facilitates personalized treatment planning for glaucoma patients.
- A valuable resource for proactive management and prevention of vision loss.
Related Concept Videos
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...