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Updated: May 29, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Rapid, in situ synthesis of bidentate ligands: chromatography-free generation of catalyst libraries
Robin Frauenlob1, Martha M McCormack, Carolyn M Walsh
1School of Chemistry, University of Dublin, Trinity College, Dublin 2, Ireland.
Abstract:
The parallel synthesis of chiral bidentate ligands and their subsequent use in situ for a catalytic process is described. The ligands thus prepared gave comparable results to those obtained when the ligands were synthesized and purified by conventional means. This includes oxazolines and other compounds of similar complexity, meaning that for the first time these valuable compounds have been brought into the field of combinatorial catalysis.
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