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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

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Borderzone strokes and transcortical aphasia.

Cécile Cauquil-Michon¹, Constance Flamand-Roze, Christian Denier

¹Department of Neurology, Bicêtre Hospital, Le Kremlin-Bicêtre, France.

Current Neurology and Neuroscience Reports

|September 10, 2011

Summary

Borderzone infarcts (BZIs), a type of stroke, can cause a specific language disorder called transcortical aphasia (TCA). This condition often improves, offering hope for stroke patients.

Area of Science:

Neurology
Stroke Medicine
Neuroscience

Background:

Borderzone infarcts (BZIs) are ischemic lesions at arterial territory junctions, representing 2-10% of strokes.
Three topographical types of hemispheric BZIs exist: superficial anterior, posterior, and deep.
Aphasia associated with BZIs is typically transcortical (TCA), marked by preserved repetition.

Purpose of the Study:

To describe the specific patterns of transcortical aphasia (TCA) in patients with borderzone infarcts (BZIs).
To investigate the evolution and prognosis of TCA in the context of BZI.
To highlight the clinical utility of recognizing this aphasic pattern for early BZI suspicion and patient management.

Main Methods:

Retrospective analysis of patients with BZIs and aphasia.

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Classification of BZI topography (anterior, posterior, deep).

Assessment of aphasia type (motor, sensory, mixed TCA) and its evolution.

Main Results:

Patients with BZI initially presented with mixed TCA.
Aphasia evolved to motor or sensory TCA based on BZI location (anterior or posterior).
TCA in BZI patients demonstrated a good long-term prognosis.

Conclusions:

A specific pattern of TCA evolution is associated with BZI.
Recognizing this pattern can aid in early BZI diagnosis, even before MRI.
This understanding facilitates tailored rehabilitation planning and patient/family counseling regarding language recovery.