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Updated: May 29, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and
Jang Kyoung Kim1, Young-Wook Won, Kwang Suk Lim
1Department of Bioengineering, Institute for Bioengineering & Biopharmaceutical Research Hanyang University, 17, Haengdang-dong, Seongdong-gu, Seoul, 133-791, Republic of Korea.
Purpose:
To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX).
Methods:
LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model.
Results:
Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40°C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX.
Conclusions:
The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.
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