Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

Metabolic States of the Body: Fasting and Starvation

Metabolic States of the Body: Fasting and Starvation

During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...

Fats as Energy Storage Molecules

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...

Fats as Energy Storage Molecules

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of regional heterogeneity of RSV infection prophylaxis on bronchiolitis in Italy.

Italian journal of pediatrics·2026

Same author

Screening practices for diabetic peripheral neuropathy in pediatric type 1 diabetes: a nationwide survey by the ISPED Diabetes Study Group.

Acta diabetologica·2026

Same author

Hajdu-Cheney Syndrome in a Two-Generation Family: Longitudinal Skeletal Progression and Differential Therapeutic Responses in a Mother and Her Son.

International journal of molecular sciences·2026

Same author

Feasibility and clinical utility of digital anthropometry for precise assessment of outcomes after post-bariatric reconstructive plastic surgery.

Frontiers in surgery·2026

Same author

Innovative digital approaches to characterize core factors of patients with late-stage knee osteoarthritis: a cross-sectional study.

Frontiers in digital health·2026

Same author

Previously Unreported <i>TMEM38B</i> Variant in Osteogenesis Imperfecta Type XIV: A Case Report and Systematic Review of the Literature.

International journal of molecular sciences·2025

Search research articles

Related Experiment Video

Updated: May 29, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

From fatness to leaness: where did we go wrong?

Angelo Pietrobelli¹, Caterina Tosi, Francesca Olivieri

¹Pediatric Unit, Verona University Medical School, Verona, Italy. angpie@tin.it

International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity

|September 13, 2011

Summary

Understanding lean mass (LM) is crucial for managing obesity. Analyzing LM estimation and its relationship with fat mass (FM) can inform personalized nutrition and treatment strategies for metabolic health.

More Related Videos

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Related Experiment Videos

Last Updated: May 29, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Area of Science:

Human physiology
Body composition analysis
Metabolic health

Background:

Adipose tissue is key for energy storage, but excess energy intake over expenditure leads to obesity.
Central adiposity increases risks for hypertension, cardiovascular disease, diabetes, and mortality.
Obesity development is linked to 'overeating' or 'under-activity', with fat mass extensively studied.

Purpose of the Study:

Analyze methodologies for estimating lean mass (LM).
Understand the interrelationship between fat mass (FM) and LM.
Highlight the importance of LM during growth and its role in body composition.

Main Methods:

Review of methodologies for lean mass estimation.
Analysis of the anatomical, biological, and pathological links between muscle and adipose tissue.
Exploration of the interrelationship between fat mass and lean mass.

Main Results:

Muscle and adipose tissue are closely interconnected, influencing obesity and physical activity-related diseases.
Lean mass estimation and programming show implications for the early origins of obesity.
The interplay between fat mass and lean mass is vital for understanding disease pathogenesis.

Conclusions:

Measuring lean mass can enhance tailored nutrition and treatment based on metabolic criteria.
Prioritizing lean mass preservation is essential for obesity prevention and treatment.
Lean mass, as metabolically active tissue, warrants focus in managing obesity.