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Gradient enhanced spectroscopy.

Peter C van Zijl1, Ralph E Hurd

  • 1The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. pvanzijl@mri.jhu.edu

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|September 13, 2011
PubMed
Summary
This summary is machine-generated.

This paper details the introduction of shielded gradient technology in Nuclear Magnetic Resonance (NMR) spectroscopy. It covers early probe design and technical progress, making the technology standard in modern NMR.

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Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Biophysics

Background:

  • The development of shielded gradient technology was crucial for advancing Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Early NMR probe design faced limitations that necessitated innovation.

Purpose of the Study:

  • To provide a historical overview of the introduction of shielded gradient technology in NMR spectroscopy.
  • To detail the technical progress and key developments that led to its widespread adoption.

Main Methods:

  • Personal recollections of key researchers involved in the technology's development.
  • Review of early technical progress in using shielded magnetic field gradients for coherence selection.
  • Examination of developments at major institutions like General Electric, NIH, Georgetown University, and Johns Hopkins University.

Main Results:

  • Shielded gradient technology significantly improved coherence selection in high-resolution NMR.
  • Collaborative efforts across academia and industry accelerated the integration of this technology.
  • The technology transitioned from specialized research to a standard feature in modern NMR spectrometers.

Conclusions:

  • The introduction of shielded gradient technology represents a significant milestone in the evolution of NMR spectroscopy.
  • Early research, primarily published in the Journal of Magnetic Resonance, laid the foundation for current NMR capabilities.
  • This technology's successful implementation highlights the impact of focused research and development in analytical instrumentation.