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Updated: May 29, 2026

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
Chip-based drug screening for inhibiting α-glucosidase
Chung-Chia Chen1, Ping-Hsien Chuang, Yueh-Sheng Chen
1Linsen-Chinese Medicine Branch, Taipei City Hospital, Taipei, Taiwan.
Abstract:
Intestinal α-glucosidase performs a physiologically vital function in the digestive process of dietary carbohydrates. Administration of an α-glucosidase inhibitor may retard the digestion and absorption of carbohydrates. Consequently, the rise in postprandial blood glucose could be suppressed. This study developed a novel technology, called "after flowing through immobilized receptor (AFTIR)," for targeting components in herbal medicines with α-glucosidase-suppressing capability. As a result, we reveal that the AFTIR system is a highly-efficient drug screening platform, capable of purifying and identifying active components with α-glucosidase-suppressing capability in herbal medicines.
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