Related Experiment Video
Updated: May 29, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Dietary fatty acid composition and metabolic syndrome in Tehranian adults
Azita Hekmatdoost1, Parvin Mirmiran, Firoozeh Hosseini-Esfahani
1Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. azizi@endocrine.ac.ir
Objective:
Several studies have shown that dietary and plasma fatty acid (FA) composition can modulate the development of metabolic syndrome, but epidemiologic data are scarce. The aim of this study was to evaluate the association between dietary FA composition and metabolic syndrome in Tehranian adults.
Methods:
Dietary FA composition and symptoms of metabolic syndrome were assessed in a population-based cross-sectional study of 822 participants (354 men and 468 women, 18-74 y old) as part of the Tehran Lipid and Glucose Study. Metabolic syndrome was defined according to the guidelines presented by the Adult Treatment Panel III.
Results:
The means ± standard deviations for dietary FA composition of total fat, linoleic acid, oleic acid, and saturated FA were 30.3 ± 7.5%, 1.43 ± 1.76%, 2.87 ± 2.19%, and 5.7 ± 2.2% of daily consumed energy, respectively. No significant correlation between the percentage of linoleic or oleic acids and metabolic syndrome was observed. Participants whose consumption of saturated FA was in the highest quartile had a significantly increased probability of acquiring metabolic syndrome (odds ratios by quartile 1, 0.83, 0.91, 0.95, P for trend <0.03). The odds ratios decreased after adjusting for indicators of a healthy lifestyle, including diet.
Conclusion:
The data from this study indicate that increased consumption of dietary total fat, especially saturated FA, is associated with a higher risk of metabolic syndrome in Tehranian adults. The relation, apparently, is influenced by an individual's lifestyle.
Related Concept Videos
Cholesterol: Significance and Regulation
Considering cholesterol and...
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Obesity
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Atherosclerosis III: Management
