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Related Experiment Video

Updated: May 29, 2026

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

Aortic dissection and cocaine use.

Gian Luca Marella¹, Carmelo Furnari, Emilio Perfetti

¹Department of Public Health, Section of Legal Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

Journal of Forensic and Legal Medicine

|September 13, 2011

Summary

Cocaine use can lead to rare aortic dissection, a serious cardiovascular complication. This case highlights the risk even when drug levels appear non-toxic.

Area of Science:

Cardiology
Toxicology
Vascular Surgery

Background:

Cardiovascular complications are the leading cause of death in cocaine users.
Aortic dissection is a rare but severe complication associated with chronic cocaine abuse.

Observation:

A 45-year-old male with a history of substance abuse experienced an aortic dissection after cocaine use.
Blood toxicology results for cocaine and benzoylecgonine were not in a typically toxic range.

Findings:

This case report details an infrequent complication of chronic cocaine use: aortic dissection.
The dissection occurred despite blood cocaine concentrations not being overtly toxic.

Implications:

Clinicians should consider aortic dissection in patients with a history of cocaine use presenting with relevant symptoms.

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Further research is needed to understand the mechanisms linking cocaine use to aortic dissection at non-toxic levels.