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Updated: May 29, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)
Published on: January 20, 2016
Light-controlled DNA binding of bisbenzamidines
Mateo I Sánchez1, Olalla Vázquez, M Eugenio Vázquez
1Departamento de Química Orgánica y Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Unidad Asociada al CSIC, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Abstract:
Caging of the amidinium moieties of two representative bisbenzamidine DNA binders with suitable photoresponsive protecting groups suppresses their DNA-binding, which can then be fully recovered upon irradiation with UV light that removes the caging groups, regenerating the parent compounds. Moreover, a caged aza-pentamidine (©1a) is inert against Candida albicans, but displays a potent growth inhibitory activity after irradiation with UV light.
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