[Arterial occlusive disease. Catheter-directed thrombolytic therapy]

Local catheter-directed thrombolysis of extremity artery or bypass thromboembolic occlusions is a promising therapeutic option with comparatively low complication rates, if the severity of the ischemia does not require urgent surgical revascularization. This therapeutic decision has to be made by a vascular team taking individual circumstances and contraindications into consideration. Apart from an adequate dosage, a strict intrathrombotic administration of the fibrinolytic agent and careful clinical monitoring including surveillance of the coagulation system is necessary and intensive care unit resources should be used. If necessary the thrombolysis therapy can be combined with mechanical thrombaspiration and balloon dilatation or surgical correction of an underlying lesion.