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Enantioselective capillary electrochromatography: recent developments and new trends
Debby Mangelings1, Yvan Vander Heyden
1Department of Analytical Chemistry and Pharmaceutical Technology, Center for Pharmaceutical Research, Vrije Universiteit Brussel, Brussels, Belgium. debby.mangelings@vub.ac.be
Electrophoresis
|September 13, 2011
Summary
Capillary electrochromatography (CEC) offers unique chiral separation capabilities but faces limitations in commercial availability and robustness. Recent applications (2006-2010) highlight its potential despite these challenges.
Area of Science:
- Analytical Chemistry
- Separation Science
Background:
- Capillary electrochromatography (CEC) combines electroosmotic flow and chromatographic separation principles.
- Despite extensive research since the 1970s, CEC remains largely academic due to limited commercial stationary phases, column fragility, and reproducibility issues.
Purpose of the Study:
- To review recent applications of CEC in enantioselective analysis between 2006 and 2010.
- To evaluate chiral selectors used in CEC for their potential in future method development and screening.
Main Methods:
- Literature review focusing on CEC applications in enantioselective analysis from 2006-2010.
- Critical discussion of stationary phases (chiral selectors) and their suitability for method development.
Main Results:
- CEC has demonstrated significant potential in chiral separations.
- Various stationary phases (chiral selectors) have been employed, showing promise for specific enantioselective analyses.
Conclusions:
- CEC remains a valuable technique for enantioselective analysis due to its unique separation mechanism.
- Further development of robust and reproducible stationary phases is crucial for broader CEC adoption.
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