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Updated: May 29, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Iron chelation therapy for transfusional iron overload: a swift evolution.

Khaled M Musallam1, Ali T Taher

  • 1Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Centre, Beirut, Lebanon.

Hemoglobin
|September 14, 2011
PubMed
Summary

Chronic iron overload from transfusions causes severe health issues. While older treatments exist, newer oral iron chelators offer improved options, though challenges remain in finding the ideal solution.

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Area of Science:

  • Hematology
  • Pharmacology
  • Internal Medicine

Background:

  • Chronic transfusional iron overload is a serious complication.
  • Iron overload leads to significant morbidity and mortality.
  • Existing treatments like deferoxamine have compliance issues.

Purpose of the Study:

  • To review the efficacy and safety of oral iron chelators.
  • To discuss the evolution of iron chelation therapy.
  • To highlight the ongoing search for ideal iron chelators.

Main Methods:

  • Literature review of iron chelator therapies.
  • Analysis of evidence for deferiprone and deferasirox.
  • Discussion of clinical experience and patient compliance.

Main Results:

  • Deferiprone and deferasirox represent advancements in oral iron chelation.
  • Evidence supports their efficacy and safety in various settings.
  • Drawbacks associated with these oral agents have been observed.

Conclusions:

  • Oral iron chelators have improved transfusional siderosis management.
  • Further research is needed to identify cost-effective and ideal iron chelators.
  • Patient compliance remains a key consideration in therapy selection.