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Related Experiment Video

Updated: May 29, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Persistent pain after mastectomy with reconstruction.

Oonagh T Hickey1, Nora F Nugent, Siun M Burke

  • 1Department of Anaesthesia, Cork University Hospital and University College, Wilton, Cork City, County Cork, Ireland. oonaghhickey@yahoo.co.uk

Journal of Clinical Anesthesia
|September 14, 2011
PubMed
Summary

Persistent postsurgical pain (PPSP) affects 43% of women after mastectomy and reconstruction, impacting function. Genetic factors, like COMT gene variations, may influence PPSP development, warranting further investigation.

Related Experiment Videos

Last Updated: May 29, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Area of Science:

  • Oncology
  • Pain Medicine
  • Genetics

Background:

  • Persistent postsurgical pain (PPSP) is a significant complication following mastectomy and breast reconstruction.
  • Understanding the prevalence and influencing factors of PPSP is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine the prevalence of PPSP after mastectomy and reconstruction.
  • To assess the impact of PPSP on functional status.
  • To examine associations between PPSP and specific gene polymorphisms (COMT and GCH1).

Main Methods:

  • Retrospective study involving 42 women who underwent mastectomy and breast reconstruction.
  • Utilized validated questionnaires for pain, function, anxiety, and depression.
  • Collected blood samples for genetic analysis of COMT and GCH1 genes.

Main Results:

  • A high prevalence of PPSP was reported in 43% of participants.
  • PPSP was associated with lower functional status scores (Patient-Specific Functional Scale).
  • A trend suggested a link between PPSP and the val158met polymorphism of the COMT gene.

Conclusions:

  • Persistent pain is common after mastectomy and breast reconstruction.
  • Genetic factors may play a role in the development of PPSP.
  • Larger studies are needed to confirm the genetic associations.