Related Experiment Video
Updated: May 29, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
Beyond the frog: the evolution of homology models of human IKKβ
Nicholas Y Palermo1, Amarnath Natarajan
1Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Abstract:
Nuclear Factor κ B is implicated in tumor progression and chronic inflammatory diseases and is regulated by IκB kinase β (IKKβ). The crystal structure of IKKβ has been recently solved for Xenopus laevis. Homology models of human IKKβ have been developed prior to and after the crystal structure was solved. Here, we compare four models of human IKKβ and evaluate their performance in both broad and focused library docking studies.
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