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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Location of visual field defects and their impact on vision-related quality of life in glaucoma: A systematic review.

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Related Experiment Video

Updated: May 29, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Cup size predicts subsequent functional change in early glaucoma.

Stuart K Gardiner1, Chris A Johnson, Shaban Demirel

  • 1Discoveries In Sight Laboratories, Devers Eye Institute, Legacy Health, Portland, Oregon 97232, USA. sgardiner@deverseye.org

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|September 14, 2011
PubMed
Summary

Structural measurements like rim area predict current visual function in early glaucoma. However, cup area, cup volume, and disc area better predict future functional decline in glaucoma patients.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma is a progressive optic neuropathy leading to vision loss.
  • Early detection and prediction of functional decline are crucial for managing glaucoma.
  • Structural parameters of the optic nerve head are key indicators in glaucoma assessment.

Purpose of the Study:

  • To identify structural predictors of functional change in patients with early glaucoma or at risk.
  • To evaluate the predictive power of different optic nerve head parameters on visual function over time.

Main Methods:

  • 129 participants with high-risk ocular hypertension, suspected, or early glaucoma were followed for 10 years.
  • Standard Automated Perimetry (SAP) measured visual function (Mean Deviation - MD).
  • Confocal Scanning Laser Ophthalmoscopy (CSLO) assessed structural parameters (rim area, cup area, cup volume, disc area).
  • Linear regression models predicted MD and its rate of change using CSLO parameters, intraocular pressure, central corneal thickness, and treatment status.

Main Results:

  • Rim area predicted current Mean Deviation (MD) with a correlation of 0.445.
  • Cup area, cup volume, and disc area showed stronger correlations in predicting the subsequent rate of change in MD (r=0.631, r=0.649, r=0.602, respectively).
  • Models using cup area, cup volume, and disc area were significantly better at predicting future functional decline compared to rim area.

Conclusions:

  • Lower rim area is predictive of worse visual function on the same date in early glaucoma.
  • Cup area, cup volume, and disc area are more predictive of the rate of subsequent functional change.
  • The choice of structural parameters for prediction should align with the specific clinical question and purpose.