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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Regulation of Food Intake

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Related Experiment Video

Updated: May 29, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Epigenetic regulation in obesity.

C Lavebratt¹, M Almgren, T J Ekström

¹Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. catharina.lavebratt@ki.se

International Journal of Obesity (2005)

|September 14, 2011

Summary

Epigenetic mechanisms regulate gene expression and metabolic processes like adipogenesis and glucose homeostasis. These epigenetic changes, influenced by environment and potentially heritable, are key to understanding metabolic disorders.

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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Area of Science:

Molecular Biology
Epigenetics
Metabolic Regulation

Background:

Cellular information transfer relies on DNA accessibility and transcription machinery.
Epigenetic mechanisms, including DNA methylation and histone modifications, control cell-type-specific gene expression.
Epigenetic marks can be plastic, responding to stimuli, or stochastic.

Purpose of the Study:

To explore the role of transient and long-term epigenetic mechanisms in adipogenesis and glucose homeostasis.
To investigate the impact of intrauterine exposures, like poor maternal nutrition, on offspring epigenotypes and metabolic programming.
To highlight the potential germline transmission of metabolic disease-related epigenotypes.

Main Methods:

Review of existing evidence from animal and human studies.
Analysis of epigenetic mechanisms such as DNA methylation, histone modifications, and small RNA interference.
Examination of developmental origins of health and disease (DOHaD) principles related to epigenetics.

Main Results:

Epigenetic mechanisms are critical regulators of adipogenesis and glucose homeostasis.
Intrauterine exposures can establish specific epigenotypes, leading to metabolic priming in offspring.
Epigenetic modifications show potential for intergenerational and germline transmission.

Conclusions:

Epigenetic regulation plays a significant role in metabolic health and disease.
Understanding epigenetic mechanisms is crucial for deciphering the complex etiology of obesity and related disorders.
Integrating epigenetic knowledge with genomic data will advance our comprehension of metabolic diseases.