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Updated: May 29, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Optimal management of severe/refractory asthma
Smita Pakhale1, Sunita Mulpuru, Matthew Boyd
1The Ottawa Hospital at the University of Ottawa, Ottawa, ON, Canada.
Severe asthma affects 300 million globally, causing difficult-to-control symptoms. This review covers severe asthma management, including pharmacologic and non-pharmacologic options for challenging cases.
Area of Science:
- Pulmonology
- Clinical Medicine
- Immunology
Background:
- Asthma is a chronic airway inflammatory disease impacting 300 million worldwide.
- Uncontrolled asthma, even with high-dose corticosteroids, leads to increased morbidity and healthcare needs.
- Managing severe asthma presents significant challenges for physicians.
Purpose of the Study:
- To define, evaluate, and discuss the prevalence of severe asthma.
- To review current pharmacologic and non-pharmacologic treatment strategies for severe asthma.
Main Methods:
- Clinical review of existing literature.
- Analysis of diagnostic criteria and treatment guidelines for severe asthma.
Main Results:
- Severe asthma is characterized by airway hyperresponsiveness and persistent symptoms.
- Current treatments include high-dose inhaled and oral corticosteroids, with varying efficacy.
- A range of pharmacologic and non-pharmacologic options exist for managing severe cases.
Conclusions:
- Effective management of severe asthma requires a comprehensive approach.
- Further research into novel therapeutic strategies is warranted.
- Optimizing treatment plans is crucial for improving outcomes in severe asthmatics.
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