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Updated: May 29, 2026

14:44
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
A general synthesis of dirhodium metallopeptides as MDM2 ligands
Alexander N Zaykov1, Zachary T Ball
1Department of Chemistry, Rice University, 6100 Main St., MS60, Houston, TX 77005, USA.
Abstract:
A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.

