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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Updated: May 29, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Advances in epigenetic technology.

Trygve O Tollefsbol1

  • 1Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA. trygve@uab.edu

Methods in Molecular Biology (Clifton, N.J.)
|September 14, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetics involves heritable phenotype changes without altering genotype. New techniques enable detailed analysis of DNA methylation and histone modifications, advancing genetic research.

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Last Updated: May 29, 2026

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Area of Science:

  • Genetics and Molecular Biology
  • Epigenetics and Genomics

Background:

  • Epigenetics encompasses heritable phenotype alterations independent of genotype.
  • Key areas include DNA methylation and histone modifications.

Discussion:

  • Numerous techniques allow analysis of epigenetic processes at gene, regional, and genome-wide levels.
  • Advances in methods for assessing epigenetic enzymes are also significant.

Key Insights:

  • Current epigenetic analysis techniques facilitate detailed examination of genomic changes.
  • These methods support the study of enzymes mediating epigenetic modifications.

Outlook:

  • The development of advanced epigenetic analysis tools is crucial for the field's rapid expansion.
  • Continued innovation in epigenetic research promises significant contributions to genetics.