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Elevated mean platelet volume is associated with impaired coronary microvascular function in patients with idiopathic

Dogan Erdogan1, Senol Tayyar, Atilla Icli

  • 1Suleyman Demirel University, Faculty of Medicine, Cardiology Department, Isparta, Turkey. aydoganer@yahoo.com

Platelets
|September 15, 2011
PubMed

Insights

Mean platelet volume (MPV) is elevated in idiopathic dilated cardiomyopathy (IDC) patients with reduced coronary flow reserve (CFR). Higher MPV levels indicate more severe microvascular dysfunction in these patients.

Area of Science:

  • Cardiology
  • Hematology
  • Vascular Biology

Background:

  • Idiopathic dilated cardiomyopathy (IDC) is associated with attenuated coronary flow reserve (CFR).
  • Increased platelet activity is observed in heart failure and left ventricular dysfunction.

Purpose of the Study:

  • To investigate if mean platelet volume (MPV) is elevated in IDC patients.
  • To determine if increased MPV correlates with coronary microvascular dysfunction in IDC.

Main Methods:

  • MPV was measured in 37 IDC patients.
  • Echocardiography and CFR measurements were performed.
  • Patients were grouped by median CFR (lower vs. normal).

Main Results:

  • MPV was significantly higher in the lower CFR group (9.00 ± 0.56 fL) versus the normal CFR group (8.25 ± 0.76 fL).
  • CFR showed a significant inverse correlation with MPV (r = -0.475, p = 0.003).
  • MPV independently predicted lower CFR (β = -0.750, p = 0.002) with 82% AUC.

Conclusions:

  • A negative correlation exists between MPV and CFR in IDC patients.
  • Elevated MPV is linked to coronary microvascular dysfunction in IDC.
  • MPV may serve as a predictor of reduced CFR in IDC.

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