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Related Experiment Video

Updated: May 29, 2026

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children
05:04

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

Published on: October 4, 2018

Risperidone rechallenge for marked liver function test abnormalities in an autistic child.

Mazlum Copur1, Ayten Erdogan

  • 1Department of Child and Adolescent Psychiatry, Bakirkoy Mental Health and Neurology and Training Research Hospital, Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi, Istanbul- Turkey. sidar1996@yahoo.com.tr

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
|September 15, 2011
PubMed
Summary

Risperidone can cause liver enzyme elevation in children, but careful management allows for continued treatment in those with autism and disruptive behaviors. This approach can lead to significant psychiatric improvement.

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Last Updated: May 29, 2026

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children
05:04

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

Published on: October 4, 2018

Area of Science:

  • Pediatric Pharmacology
  • Neurodevelopmental Disorders
  • Hepatology

Background:

  • Risperidone is frequently associated with asymptomatic liver enzyme elevation in adults and children.
  • Severe hepatotoxicity from risperidone, though rare, is a concern in the pediatric population.
  • Autism spectrum disorder with disruptive behaviors is a challenging condition in pediatric patients.

Observation:

  • A 5-year-old male with autism and severe disruptive behavior showed significant improvement with risperidone.
  • Initial elevation of liver enzymes during risperidone treatment was observed.
  • A multidisciplinary approach involving temporary withdrawal and careful reintroduction of risperidone was employed.

Findings:

  • Risperidone can be cautiously rechallenged in pediatric patients experiencing liver enzyme elevation.
  • Successful management of elevated liver enzymes allowed for continued risperidone therapy.
  • Marked psychiatric improvement was achieved in the patient despite initial hepatotoxicity concerns.

Implications:

  • This case suggests a potential strategy for managing risperidone-induced liver enzyme elevation in children with autism.
  • Careful monitoring and a multidisciplinary approach may enable the use of risperidone for significant behavioral improvements.
  • Further research into risperidone delivery systems for autism treatment is warranted.