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Updated: May 29, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
[Combining CT and scintigraphy: SPECT-CT and PET-CT]
S Vöö1, T M A van Dongen, J J Waterval
1Universitair Medisch Centrum, Maastricht.
Hybrid bone imaging like SPECT-CT and PET-CT offers superior diagnostic accuracy for skeletal conditions compared to traditional bone scans. These advanced techniques aid in detecting metastases and evaluating bone metabolism.
Area of Science:
- Nuclear Medicine
- Radiology
- Medical Imaging
Background:
- Conventional bone scintigraphy lacks the diagnostic accuracy of newer tomographic hybrid scanners.
- Single-photon emission computed tomography (SPECT)-CT and positron emission tomography (PET)-CT are increasingly adopted in nuclear medicine.
Purpose of the Study:
- To compare the diagnostic accuracy and characteristics of SPECT-CT and PET-CT bone imaging with conventional bone scintigraphy.
- To highlight the key differences in image quality, technique, and cost between these modalities.
Main Methods:
- Comparison of SPECT-CT (using 99mTc-HDP or 99mTc-MDP) and 18F-fluoride PET-CT bone scanning.
- Evaluation of diagnostic accuracy, image quality, technique, availability, quantification, dosimetry, and cost.
Main Results:
- SPECT-CT and PET-CT demonstrate higher diagnostic accuracy than conventional bone scans.
- Differences exist in image quality, technique, quantification, dosimetry, and cost between SPECT-CT and PET-CT.
Conclusions:
- Hybrid SPECT-CT and PET-CT are valuable for detecting skeletal metastases and evaluating unexplained musculoskeletal pain.
- These advanced techniques offer improved diagnostic capabilities for bone metabolism quantification and staging after conventional imaging.
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