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One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode
Published on: June 18, 2016
[Clinical variants of chronic urticaria associated with Helicobacter pylori]
Insights
Helicobacter pylori (HP) eradication can lead to remission in 20.5% of chronic idiopathic urticaria patients with gastrointestinal issues. However, HP eradication is not recommended for treating or preventing allergic urticaria.
Area of Science:
- Gastroenterology
- Immunology
- Infectious Diseases
Background:
- Chronic urticaria (CU) presents diagnostic challenges, with causes often remaining unclear in 70-90% of cases.
- Helicobacter pylori (HP) infection is increasingly recognized for its potential role in CU development and persistence.
- The impact of HP eradication on CU outcomes requires further investigation.
Purpose of the Study:
- To enhance the diagnosis and treatment strategies for urticaria patients co-existing with Helicobacter-associated upper gastrointestinal diseases.
- To investigate the efficacy of HP eradication in managing chronic idiopathic urticaria and allergic urticaria.
Main Methods:
- The study involved 184 patients aged 18 and above presenting with urticaria and diagnosed HP-associated gastroduodenal pathology.
- Assessed the prevalence of HP infection and related gastrointestinal conditions (gastritis, gastric/duodenal ulcers) in urticaria patients.
- Monitored the outcomes of HP eradication therapy, including remission rates and recurrence of urticaria symptoms.
Main Results:
- HP infection was more prevalent in chronic idiopathic urticaria (73%) than allergic urticaria (56%).
- HP-associated chronic gastritis was common in both groups (90% AU, 81% CU), alongside gastric and duodenal ulcers.
- Successful HP eradication was achieved in 69.2% (AU) and 61.8% (CU) of patients, with 20.5% of CU patients experiencing no recurrence within a year.
Conclusions:
- Helicobacter pylori eradication therapy is recommended for patients with idiopathic urticaria and associated gastrointestinal diseases, potentially leading to remission or reduced exacerbations.
- HP eradication is not considered a reasonable treatment or preventive measure for allergic urticaria.
- Prognostic factors for stable CU remission post-HP eradication include specific antibody levels (IgG-AP), serum cytokines (IL-1β, TNF-α), and total IgE levels.
Introduction:
Chronic urticaria (CU) is one of the toughest problems. The main difficulty is the search for an etiological factor in 70-90% of cases the cause of chronic urticaria remains unclear. In the development and persistence of CU recently paid great importance to the role of Helicobacter pylori infection (HP), which is the most common bacterial infection in humans. However, the influence of HP eradication on the course of CU is poorly understood.
Aim:
to improve the diagnosis and treatment of urticaria patients with Helicobacter-associated diseases of the upper gastrointestinal tract.
Materials And Methods:
The study included 184 patients with clinical manifestations of urticaria and HP-associated gastroduodenal pathology in the age of 18.
Results:
Infection with HP was more frequently detected in patients with chronic idiopathic urticaria in comparison with patients with allergic urticaria (73% and 56% respectively, p < 0.05). In patients with allergic and chronic idiopathic urticaria HP-associating chronic gastritis were detected respectively in 90% and 81% of cases, gastric ulcer (4% and 11%) and duodenal ulcers (6% and 13%) in the first and second groups, respectively (p < 0.05). HP eradication was achieved in 69.2% of patients in the group with AU and 61.8% of patients with CU, while in 20.5% of patients with CU didn't recur in the year. The influence of HP eradication on the course of allergic urticaria isn't established. In order to achieve stable remission CU by HP eradication in patients with diseases of the digestive tract of prognostically important is the combination of the following factors: the initial elevated levels of antibodies to HP (IgG-AP) in the range of 1:360 to 1:900, serum cytokines: interleukin 1beta in the range (68-22 pg/ml) and TNF alpha (84-50 pg/ml), reduced levels of total IgE from 0 to 38 IU/ml.
Conclusion:
To patients with HP-associated gastrointestinal diseases, combined with idiopathic urticaria is shown holding Helicobacter therapy, because it leads to remission of allergies at 20.5% of patients remaining--to reduce the frequency of exacerbations. To patients with allergic urticaria an HP eradication for the treatment and prevention of AK is not reasonable.
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