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Updated: May 29, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Synthesis of fused carbocycles via a selective 6-endo dig gold(I)-catalyzed carbocyclization
Francis Barabé1, Patrick Levesque, Ilia Korobkov
1Centre for Catalysis Research and Innovation, Department of Chemistry, 10 Marie Curie, University of Ottawa, Ottawa, Canada, K1N 6N5.
Abstract:
A gold-catalyzed synthesis of fused carbocycles via a regioselective 6-endo dig process is reported. The selectivity can be modulated by the steric and electronic properties of gold(I) complexes. The ligands can influence the pathway selectivity for the first bond formation rather than through a common intermediate generated after an initial bond formation. This gold(I)-catalyzed transformation provides access to synthetically useful carbocyclic motifs that are found in numerous diterpenoid natural products.
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