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Updated: May 29, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

Implication of miRNA in the diagnosis and treatment of breast cancer

Carlos A Castañeda1, María Teresa Agullo-Ortuño, Juan Angel Fresno Vara

  • 1Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú

Expert Review of Anticancer Therapy
|September 16, 2011
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in breast cancer (BC) biology, influencing gene expression and disease progression. Understanding miRNA profiles can improve BC prognosis and treatment strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Breast cancer (BC) is a complex disease involving alterations in tissue structure and gene expression.
  • MicroRNAs (miRNAs) are small noncoding RNAs that regulate a significant portion of human genes.
  • The role of miRNAs in cancer, particularly BC, is a growing area of scientific interest.

Purpose of the Study:

  • To explore the association between miRNA expression profiles and BC characteristics.
  • To highlight miRNAs as potential biomarkers for BC prognosis and patient management.
  • To discuss the potential of miRNA-targeted therapies for improving BC treatment.

Main Methods:

  • Review of recent studies on miRNA expression in breast cancer.
  • Analysis of the link between miRNA profiles and pathological/clinical BC features.
  • Investigation of miRNA networks and their impact on BC biology.

Main Results:

  • miRNA expression profiles are associated with pathological and clinical features of BC.
  • miRNAs show potential as molecular markers for predicting BC prognosis.
  • Understanding miRNA networks offers insights into BC pathogenesis.

Conclusions:

  • miRNAs play a crucial role in the molecular landscape of breast cancer.
  • miRNA expression profiling holds promise for personalized BC management.
  • Targeting specific miRNAs may lead to novel therapeutic strategies for BC.

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