Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential and challenges of generative adversarial networks for super-resolution in 4D flow MRI.

Computers in biology and medicine·2026
Same author

Uncertainty Quantification for Cardiac Diffusion Tensor Imaging Without Additional Datasets.

Magnetic resonance in medicine·2026
Same author

Flow-dependent nanodrug targeting for atherosclerosis prevention.

Cardiovascular research·2026
Same author

Neural implicit heart coordinates: 3D cardiac shape reconstruction from sparse segmentations.

Medical image analysis·2026
Same author

Deep Learning for Temporal Super-Resolution 4D Flow MRI.

IEEE transactions on medical imaging·2026
Same author

A concentric tube catheter for endoluminal interventions, steered and imaged via magnetic resonance imaging.

Communications engineering·2026

Related Experiment Video

Updated: May 29, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and

Alistair A Young1, Debra J Medway, Craig A Lygate

  • 1Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand. a.young@auckland.ac.nz

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|September 16, 2011
PubMed
Summary

Three-dimensional guide-point modeling (GPM) accurately assesses cardiac function in mice using fewer cardiac magnetic resonance imaging slices. This method reduces scan time while maintaining reliable quantification of left-ventricular (LV) mass and volumes.

More Related Videos

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
09:05

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

Published on: June 21, 2016

Related Experiment Videos

Last Updated: May 29, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
09:05

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

Published on: June 21, 2016

Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Animal Models

Background:

  • Cardiac magnetic resonance imaging (CMR) is crucial for evaluating global cardiac function.
  • Quantifying left-ventricular (LV) mass and volumes traditionally requires numerous image slices, increasing scan time.
  • Reducing the number of slices can improve efficiency but may impact accuracy.

Purpose of the Study:

  • To assess the efficacy of three-dimensional guide-point modeling (GPM) in reducing CMR scan time for murine cardiac function analysis.
  • To determine if GPM can maintain accurate quantification of LV mass and volumes with fewer image slices.
  • To investigate GPM's utility in both healthy and infarcted mouse hearts.

Main Methods:

  • CMR examinations were performed on C57Bl/6 mice, including those with induced myocardial infarction and healthy controls.
  • Short-axis (SAX) and long-axis (LAX) slices were acquired.
  • GPM was applied using full, six-slice, and four-slice protocols, with results compared to standard manual analysis.

Main Results:

  • No significant differences in LV mass and volumes were observed between standard and GPM full/six-slice protocols in infarcted mice.
  • No significant differences were found between standard and GPM full, six, or four-slice protocols in control mice.
  • Significant differences in LV mass and ejection fraction (EF) were noted with the GPM four-slice protocol in infarcted mice.

Conclusions:

  • GPM facilitates accurate LV function analysis in mice with significant infarcts using a reduced six-slice protocol.
  • GPM enables accurate analysis in mice with normal LV topology using a four-slice protocol.
  • This modeling approach enhances efficiency in cardiac function assessment in mouse models.