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Related Experiment Videos

Corneal changes in Tay-Sachs disease.

M Ghosh1, W S Hunter, C Wedge

  • 1Department of Ophthalmology, University of Toronto, Ont.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|June 1, 1990
PubMed
Summary

Tay-Sachs disease, an inherited disorder causing ganglioside buildup, was observed in a non-Jewish infant. Pathologic changes occurred in both the retina and corneal endothelium.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Neurology

Background:

  • Tay-Sachs disease is a rare inherited metabolic disorder.
  • It is characterized by the accumulation of gangliosides in neural tissues, primarily the brain and retina.
  • While often associated with Ashkenazi Jewish populations, Tay-Sachs disease can occur in individuals of any ethnicity.