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Short-term corticosteroids for celiac crisis in infants
Nedeljko P Radlovic1, Marija M Mladenovic, Zorica M Stojsic
1Department of Gastroenterology and Nutrition, University Childrens Hospital, Belgrade, Serbia. n.radlovic@beotel.net
Insights
Celiac crisis in infants can cause persistent diarrhea. Corticosteroid therapy rapidly resolved symptoms in two infants, even after dietary changes and nutritional support failed.
Area of Science:
- Pediatrics
- Gastroenterology
- Immunology
Background:
- Celiac crisis is a rare but severe presentation of celiac disease in infants.
- Persistent secretory diarrhea can occur despite standard management, including gluten-free and lactose-free diets and parenteral nutrition.
- Treatment options for refractory celiac crisis are limited.
Abstract:
We report two infants with celiac crisis who continued to have persistent secretory diarrhea despite gluten and lactose free diet and supportive parenteral nutrition. The children were given corticosteroid therapy. After a five-day oral prednisone in the dose of 2 mg/kg/daily, both patients rapidly recovered.
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