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Related Concept Videos

Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genetic Lingo01:11

Genetic Lingo

Overview
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Inheritance01:25

Inheritance

Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype traits...

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Related Experiment Video

Updated: May 29, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Host genetics.

Juan Macías1, Eugenia Vispo, Juan A Pineda

  • 1Infectious Diseases and Microbiology Unit, Hospital Universitario de Valme, Seville, Spain.

Current Opinion in HIV and AIDS
|September 16, 2011
PubMed
Summary

Genetic markers near the IL28B gene influence hepatitis C virus (HCV) clearance and treatment response. IL28B genotyping can guide treatment decisions for HCV infection.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Virology

Background:

  • Genetic factors significantly impact the host's immune response to Hepatitis C Virus (HCV) infection.
  • Interferon-lambda 3 (IFN-λ3), encoded by the IL28B gene, plays a crucial role in viral clearance.
  • Understanding these genetic influences is key to optimizing treatment strategies for HCV.

Purpose of the Study:

  • To review and update current knowledge on genetic markers, particularly IL28B gene variations, that influence the outcome of HCV infection.
  • To assess the role of these markers in spontaneous clearance, treatment response, and disease progression.
  • To evaluate the clinical utility of genetic profiling in managing HCV.

Main Methods:

  • Review of scientific literature focusing on genetic polymorphisms and their association with HCV infection outcomes.

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Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

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  • Analysis of data on single-nucleotide polymorphisms (SNPs) in the IL28B gene region.
  • Examination of studies investigating the correlation between IL28B genotypes and sustained virological response (SVR) to antiviral therapies.

    • Main Results:

    • Single-nucleotide polymorphisms (SNPs) in the IL28B gene region, specifically rs12979860, are strongly associated with spontaneous and treatment-induced HCV clearance.
    • The rs12979860 CC genotype significantly increases the rate of sustained virological response (SVR) to pegylated-interferon plus ribavirin (Peg-IFN/RBV) in HCV genotypes 1 and 4.
    • IL28B variants influence SVR rates differently across HCV genotypes and show varying frequencies in diverse ancestral populations. Inosine triphosphatase genotype predicts ribavirin-induced anemia.

    Conclusions:

    • IL28B genotyping provides valuable information for clinical decision-making regarding Peg-IFN/RBV therapy for HCV.
    • Genetic profiling, especially IL28B status, can assist in selecting patients for combination therapies, including direct-acting antiviral drugs.
    • Further research into the mechanisms underlying IL28B's influence on liver inflammation and IFN-stimulated gene expression is warranted.