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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

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Published on: February 23, 2014

[Pulmonary non-infectious diseases in common variable immunodeficiency].

C Bron¹, E Catherinot, J Cadranel

¹Service de Pneumologie, Hôpital Foch, 40, rue Worth, 92150 Suresnes, France. camillebron@hotmail.com

Revue De Pneumologie Clinique

|September 17, 2011

Summary

This summary is machine-generated.

Common variable immunodeficiency (CVID) patients can develop non-infectious lung diseases. This study found a wide range of pulmonary non-infectious diseases in CVID patients, highlighting the need for awareness beyond infections.

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Last Updated: May 29, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

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Published on: February 23, 2014

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4⁺ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

Area of Science:

Pulmonology
Immunology
Internal Medicine

Context:

Common variable immunodeficiency (CVID) primarily presents with recurrent infections.
Pulmonary non-infectious diseases (PNID) are less frequently described in CVID patients.
Understanding PNID spectrum in CVID is crucial for comprehensive patient management.

Purpose:

To analyze the characteristics and spectrum of pulmonary non-infectious diseases (PNID) in patients with common variable immunodeficiency (CVID).
To retrospectively review PNID cases in CVID patients from two Parisian pneumology departments (1990-2008).

Summary:

Eleven CVID patients with PNID were identified, with a mean immunoglobulin serum level of 3.46g/L.
Observed PNID included arteriovenous pulmonary fistula (3), interstitial lung disease (3), asthma (2), mediastinal lymphadenopathy (4), emphysema (1), and mesothelioma (1).
The study highlights a broad range of pulmonary manifestations associated with CVID.

Impact:

Clinicians should consider PNID in CVID patients, even in the absence of typical infectious symptoms.
This research expands the understanding of CVID complications beyond infections.
Raises awareness for early diagnosis and management of PNID in CVID patients.