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[Exploring the responsible gene for a familial ALS by next-generation sequencer]

Tadashi Kaname1, Akira Tsujino, Koichiro Yoshiura

  • 1Department of Medical Genetics, University of the Ryukyus Graduate School of Medicine, Nishihara, Okinawa, Japan.

Rinsho Shinkeigaku = Clinical Neurology
|September 17, 2011
PubMed
Summary

No abstract available in PubMed .

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Although all next-generation methods use different technologies, they all share a set of standard features.

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