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The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
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Published on: March 8, 2019

Renal-pulmonary crosstalk.

Kai Singbartl1

  • 1Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pa., USA.

Contributions to Nephrology
|September 17, 2011
PubMed
Summary
This summary is machine-generated.

Acute kidney injury (AKI) and acute lung injury (ALI) significantly reduce survival due to organ interactions and inflammation. Current treatments are supportive, highlighting the need for novel therapeutic strategies.

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Last Updated: May 29, 2026

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
07:29

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09:23

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Published on: February 11, 2017

Area of Science:

  • Nephrology
  • Pulmonology
  • Critical Care Medicine

Background:

  • Acute kidney injury (AKI) and acute lung injury (ALI) are significant clinical challenges, often occurring together.
  • Kidney-lung interactions are well-documented, leading to reduced patient survival.
  • Organ failure involves direct functional loss and inflammatory dysregulation.

Purpose of the Study:

  • To review the current understanding of kidney-lung interactions in critical illness.
  • To discuss the mechanisms of inflammatory dysregulation in AKI and ALI.
  • To highlight the limitations of current therapeutic interventions and the need for future research.

Main Methods:

  • Review of clinical and experimental studies on kidney-lung crosstalk.
  • Analysis of inflammatory mediators (cellular and soluble) in AKI/ALI.
  • Evaluation of current supportive management strategies for AKI and ALI.

Main Results:

  • AKI and ALI involve complex interactions, impacting survival.
  • Inflammatory mediators, including neutrophils and cytokines, play a key role in organ crosstalk.
  • Current interventions for AKI (e.g., renal replacement therapy) and ALI (e.g., lung protective ventilation) are primarily supportive.

Conclusions:

  • The interplay between AKI and ALI exacerbates organ dysfunction and inflammation.
  • Existing treatments for AKI and ALI are limited in addressing the underlying inflammatory dysregulation.
  • Further research is crucial to develop targeted therapies for multiorgan failure involving kidney and lung injury.