Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Redox Reactions01:27

Redox Reactions

Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
Role of Reduced Coenzymes NADH and FADH₂01:29

Role of Reduced Coenzymes NADH and FADH₂

The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:â—Ź Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detected residual venous thrombi and catheter-directed management of intermediate-risk pulmonary thromboembolism.

Frontiers in cardiovascular medicine·2026
Same author

Thin Glomerular Basement Membrane Phenotypes With No Identified Pathogenic <i>COL4A3/A4/A5</i> Variant.

Kidney international reports·2026
Same author

The Impact of Sodium Glucose Transporter 2 Inhibitors on Renal Parenchymal Oxygenation: An Unsettled Issue?

Kidney360·2026
Same author

A Switch in Iron Delivery Is Critical for Postnatal Kidney Development.

Kidney360·2026
Same author

Amino acid infusion and SGLT2 inhibitors for kidney protection: Plausible adverse impact of tubular transport load on renal tissue oxygenation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis.

The New England journal of medicine·2026
Same journal

Adsorption of Pathogens and Blockade of Sepsis Cascade.

Contributions to nephrology·2023
Same journal

Hemoadsorption: Research Agenda and Potential Future Applications.

Contributions to nephrology·2023
Same journal

Hemoperfusion in Poisoning and Drug Overdose.

Contributions to nephrology·2023
Same journal

Hemoperfusion in Burns.

Contributions to nephrology·2023
Same journal

Sequential Extracorporeal Therapy in Sepsis.

Contributions to nephrology·2023
Same journal

The Use of Adsorption in Extracorporeal Liver Support: The Double Plasma Molecular Adsorption System (DPMAS).

Contributions to nephrology·2023
See all related articles

Related Experiment Video

Updated: May 29, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

A role for oxidative stress.

Samuel N Heyman, Seymour Rosen, Christian Rosenberger

    Contributions to Nephrology
    |September 17, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Sepsis-induced acute kidney injury (AKI) involves oxidative stress and hypoxia, but their exact roles are complex. Antioxidants may help manage sepsis-associated renal dysfunction as part of a broader treatment strategy.

    More Related Videos

    Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
    10:24

    Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

    Published on: June 7, 2018

    Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
    09:33

    Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

    Published on: February 7, 2018

    Related Experiment Videos

    Last Updated: May 29, 2026

    Analysis of Oxidative Stress in Zebrafish Embryos
    11:05

    Analysis of Oxidative Stress in Zebrafish Embryos

    Published on: July 7, 2014

    Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
    10:24

    Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

    Published on: June 7, 2018

    Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
    09:33

    Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

    Published on: February 7, 2018

    Area of Science:

    • Nephrology
    • Critical Care Medicine
    • Pathophysiology

    Background:

    • Sepsis-induced acute kidney injury (AKI) pathogenesis remains unclear.
    • Potential mechanisms include hemodynamic changes, renal hypoxia, and direct tubular toxicity.
    • Oxidative stress, via reactive oxygen species (ROS), contributes to renal damage and dysfunction.

    Purpose of the Study:

    • To review evidence on oxidative and nitrosative stress in sepsis-induced AKI.
    • To explore the complex interplay between ROS, hypoxia, inflammation, and renal dysfunction.
    • To evaluate the potential therapeutic role of antioxidants.

    Main Methods:

    • Literature review of studies investigating sepsis-induced AKI.
    • Analysis of evidence linking oxidative stress, nitrosative stress, and renal pathophysiology.
    • Examination of the interactions between systemic and intrarenal factors.

    Main Results:

    • Sepsis is associated with significant systemic and intrarenal oxidative and nitrosative stress.
    • Reactive oxygen species (ROS) generation is linked to inflammation and tissue hypoxia.
    • Complex interactions obscure the independent role of oxidative stress in sepsis-induced AKI.

    Conclusions:

    • Oxidative and nitrosative stress are implicated in sepsis-induced AKI pathogenesis.
    • Alleviating oxidative stress alone is unlikely to prevent sepsis-associated renal dysfunction.
    • Integrating antioxidants into comprehensive treatment strategies is a promising approach.