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Dissociative Disorders01:27

Dissociative Disorders

Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Amnesia01:21

Dissociative Amnesia

Dissociative amnesia is a complex psychological condition that manifests as an inability to recall personal information, often tied to traumatic or stressful events. Unlike general amnesia, individuals with this condition retain the ability to perform routine activities and procedural tasks, such as operating a phone or navigating public transportation, yet experience profound gaps in autobiographical memory. These lapses may encompass significant life events, such as suicide attempts or...
Dissociative Identity Disorder01:30

Dissociative Identity Disorder

Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

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Related Experiment Video

Updated: May 29, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Topiramate-induced Dissociative Disorder.

Sajjad R Sarwar1, Ronald A McGinnis

  • 1Department of Psychiatry, University of Toledo, Toledo, Ohio, USA. sajjad.sarwar@utoledo.edu

Innovations in Clinical Neuroscience
|September 17, 2011
PubMed
Summary

Topiramate, used for migraine headaches, can cause dissociative episodes. These symptoms resolved after discontinuing the medication, with no recurrence during follow-up.

Area of Science:

  • Neurology
  • Psychiatry

Background:

  • Topiramate is a medication prescribed for conditions including migraine headaches.
  • Psychiatric and neurocognitive side effects are known potential adverse events associated with topiramate use.

Observation:

  • A case study involving a 21-year-old female patient treated with topiramate for migraines.
  • The patient experienced episodes of dissociation, a psychiatric side effect.
  • Dissociative episodes correlated with topiramate dosage, increasing with higher doses and decreasing with lower doses.

Findings:

  • Topiramate treatment was associated with dose-dependent dissociative episodes in a young woman.
  • Discontinuation of topiramate led to the complete resolution of dissociative symptoms.
  • A 23-week follow-up confirmed no relapse of these side effects after stopping the medication.
Keywords:
Topiramatedissociative disorder

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Last Updated: May 29, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Implications:

  • This case highlights a potential link between topiramate and dissociative side effects.
  • Clinicians should be aware of dissociation as a possible adverse reaction to topiramate.
  • Further research may be warranted to explore the neurobiological mechanisms underlying topiramate-induced dissociation.