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Updated: May 29, 2026
10:49
Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
[Rotavirus vaccine]
1Department of Pediatrics, Osaka Rosai Hospital.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 20, 2011
Summary
A new rotavirus vaccine is effective and safe for Japanese infants. Vaccination can significantly reduce the burden of rotavirus gastroenteritis, a common cause of hospitalization in young children.
Area of Science:
- Pediatrics
- Vaccinology
- Infectious Diseases
Context:
- Rotavirus is a leading cause of severe gastroenteritis in children globally, responsible for significant mortality and morbidity.
- In Japan, rotavirus gastroenteritis leads to numerous doctor visits and hospitalizations annually among children under five.
- Current treatment options in Japan are limited to supportive care, with no specific antiviral therapies available.
Purpose:
- To evaluate the efficacy, reactogenicity, safety, and immunogenicity of a human rotavirus vaccine in Japanese infants.
- To assess the vaccine's potential to reduce the disease burden of rotavirus gastroenteritis in Japan.
Summary:
- A phase III, randomized, double-blind study was conducted to assess a human rotavirus vaccine in Japanese infants.
- The study demonstrated that the rotavirus vaccine is efficacious, well-tolerated, and immunogenic in this population.
- Results indicate the vaccine's potential for widespread use in preventing rotavirus infections.
Impact:
- Introduction of rotavirus vaccination in Japan could substantially decrease the incidence of severe gastroenteritis and related healthcare utilization.
- The findings support the public health strategy of rotavirus immunization for young children.
- This vaccine offers a promising preventive measure against a significant pediatric infectious disease.
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