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Updated: May 29, 2026
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
[Methylation of insulin-like growth factor binding protein 3 gene in neonates with intrauterine growth restriction]
Ai-Ling Su1, Li Jiang, Qin-Yu Ge
1Department of Pediatrics, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
Objective:
To study the role of promoter methylation of insulin-like growth factor binding protein 3 (IGFBP3) in intrauterine growth restriction (IUGR).
Methods:
Fifty neonates with IUGR and 30 healthy neonates were enrolled. The promoter methylation status of IGFBP3 in peripheral blood was evaluated by methylation-specific PCR (MSP) and high resolution melting (HRM) techniques.
Results:
The complete methylation rate, partial methylation rate and non-methylation rate of IGFBP3 promoter in the IUGR group was 4% (2/50), 40% (20/50) and 56% (28/50), respectively. The partial methylation rate and non-methylation rate of IGFBP3 promoter in the control group were 13% (4/30) and 87% (26/30), respectively. There were significant differences in the promoter methylation rate of IGFBP3 between the two groups (P<0.01).
Conclusions:
The promoter methylation of IGFBP3 gene is associated with the pathogenesis of IUGR.
