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Rapid and Efficient Zebrafish Genotyping Using PCR with High-resolution Melt Analysis
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Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish.

Matthew D Clark1, Victor Guryev, Ewart de Bruijn

  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

Methods in Cell Biology
|September 20, 2011
PubMed
Summary

Positional cloning of mutations is slow. New SNP panels significantly accelerate this process using advanced genotyping technologies and genetic resources.

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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...