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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis
Hugues Ouellet1, Jonathan B Johnston, Paul R Ortiz de Montellano
1Department of Pharmaceutical Chemistry, University of California at San Francisco, Genentech Hall, N572D, 600 16th Street, San Francisco, CA 94158-2517, USA.
Abstract:
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that infects 10 million people worldwide and kills 2 million people every year. The uptake and utilization of nutrients by Mtb within the host cell is still poorly understood, although lipids play an important role in Mtb persistence. The recent identification of a large regulon of cholesterol catabolic genes suggests that Mtb can use host sterol for infection and persistence. In this review, we report on recent progress in elucidation of the Mtb cholesterol catabolic reactions and their potential utility as targets for tuberculosis therapeutic agents.
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