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Related Concept Videos

Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...

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Related Experiment Video

Updated: May 29, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Transcription factor networks in dendritic cell development.

Ansuman T Satpathy1, Kenneth M Murphy, Wumesh KC

  • 1Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

Seminars in Immunology
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) develop from bone marrow, requiring specific cytokines and transcription factors for differentiation. Understanding these factors is key to controlling immune responses and promoting tolerance.

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

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Related Experiment Videos

Last Updated: May 29, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging
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Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging

Published on: July 9, 2008

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Area of Science:

  • Immunology
  • Cell Biology
  • Hematopoiesis

Background:

  • Dendritic cells (DCs) are crucial immune cells originating from bone marrow precursors within the mononuclear phagocyte system (MPS).
  • The precise commitment and specification of hematopoietic progenitors to the DC lineage are essential for initiating effective immunity and maintaining immune tolerance.
  • DCs represent a heterogeneous population, necessitating a detailed understanding of their developmental pathways.

Purpose of the Study:

  • To review the critical cytokines and transcription factors governing dendritic cell (DC) differentiation and subset diversification.
  • To highlight recent advancements in identifying immediate DC precursors derived from the common myeloid progenitor (CMP).
  • To emphasize the temporal dynamics of regulatory factors influencing DC developmental trajectories.

Main Methods:

  • Literature review of cytokines and transcription factors involved in DC development.
  • Analysis of recent studies characterizing common myeloid progenitor (CMP) derivatives.
  • Examination of temporal gene expression patterns in DC lineage commitment.

Main Results:

  • Key cytokines and transcription factors essential for DC lineage commitment and differentiation have been identified.
  • Immediate precursors to DCs originating from the common myeloid progenitor (CMP) are increasingly characterized.
  • The temporal expression of regulatory factors plays a significant role in directing DC developmental pathways.

Conclusions:

  • Cytokines and transcription factors are pivotal in directing dendritic cell (DC) differentiation and subset specification.
  • Understanding the early progenitors and their regulatory factors is crucial for harnessing DCs in immunotherapy and tolerance induction.
  • This review provides a comprehensive overview of the molecular mechanisms governing DC development from hematopoietic stem cells.