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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Updated: May 29, 2026

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
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Responsive layer-by-layer materials for drug delivery.

Benjamin M Wohl1, Johan F J Engbersen

  • 1Department of Biomedical Chemistry, MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

Responsive layer-by-layer (LbL) assembly materials are advancing drug delivery. This review details four key mechanisms enabling responsive LbL films for controlled therapeutic release.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Layer-by-layer (LbL) assembly is a versatile technique for developing advanced materials.
  • Responsive LbL materials are crucial for controlled drug and gene delivery applications.
  • Recent advancements focus on enhancing the responsiveness of LbL films.

Purpose of the Study:

  • To review the mechanisms of responsiveness in LbL films.
  • To highlight recent progress in responsive LbL material development.
  • To discuss the role of responsiveness in drug and gene delivery.

Main Methods:

  • Identification of four fundamental mechanisms in responsive LbL films.
  • Analysis of layer interaction disruption.
  • Review of degradation, physical stimuli-induced destruction, and phase transition mechanisms.

Main Results:

  • Four primary mechanisms driving LbL film responsiveness identified.
  • Significant progress in designing LbL materials with tunable responses.
  • Demonstrated utility in therapeutic loading and triggered release.

Conclusions:

  • Responsive LbL films offer significant potential for drug and gene delivery.
  • Understanding these mechanisms is key to optimizing delivery systems.
  • Continued research promises further innovation in smart LbL materials.