Related Experiment Video

Updated: May 29, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation

Jelle de Wit1, Yuri Souwer, Astrid J van Beelen

  • 1Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Blood
|September 20, 2011
PubMed
Summary

Alternative costimulation via CD5 or CD6 receptors, not CD28, enhances human Th17 cell development. CD5 signaling promotes IL-23 receptor expression, crucial for stable Th17 differentiation and IL-17 production.

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